Antagonism of Tumoral Prolactin Receptor Promotes Autophagy-Related Cell Death

Antagonism of Tumoral Prolactin Receptor Promotes Autophagy-Related Cell Death

Summary: Therapeutic upregulation of macroautophagy in cancer cells provides an alternative mechanism for cell death. Prolactin (PRL) and its receptor (PRLR) are considered attractive therapeutic targets because of their roles as growth factors in tumor growth and progression. We utilized G129R, an...

Full description

Bibliographic Details
Main Authors: Yunfei Wen, Behrouz Zand, Bulent Ozpolat, Miroslaw J. Szczepanski, Chunhua Lu, Erkan Yuca, Amy R. Carroll, Neslihan Alpay, Chandra Bartholomeusz, Ibrahim Tekedereli, Yu Kang, Rajesha Rupaimoole, Chad V. Pecot, Heather J. Dalton, Anadulce Hernandez, Anna Lokshin, Susan K. Lutgendorf, Jinsong Liu, Walter N. Hittelman, Wen Y. Chen, Gabriel Lopez-Berestein, Marta Szajnik, Naoto T. Ueno, Robert L. Coleman, Anil K. Sood
Format: Article
Language:English
Published: Elsevier 2014-04-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124714001879

Internet

http://www.sciencedirect.com/science/article/pii/S2211124714001879

Similar Items