Controlled human malaria infection with Plasmodium falciparum demonstrates impact of naturally acquired immunity on virulence gene expression.

Controlled human malaria infection with Plasmodium falciparum demonstrates impact of naturally acquired immunity on virulence gene expression.

The pathogenesis of Plasmodium falciparum malaria is linked to the variant surface antigen PfEMP1, which mediates tethering of infected erythrocytes to the host endothelium and is encoded by approximately 60 var genes per parasite genome. Repeated episodes of malaria infection result in the gradual...

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Bibliographic Details
Main Authors: Anna Bachmann, Ellen Bruske, Ralf Krumkamp, Louise Turner, J Stephan Wichers, Michaela Petter, Jana Held, Michael F Duffy, B Kim Lee Sim, Stephen L Hoffman, Peter G Kremsner, Bertrand Lell, Thomas Lavstsen, Matthias Frank, Benjamin Mordmüller, Egbert Tannich
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-07-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1007906

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https://doi.org/10.1371/journal.ppat.1007906

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