Oxidative brain damage in Mecp2-mutant murine models of Rett syndrome

Oxidative brain damage in Mecp2-mutant murine models of Rett syndrome

Rett syndrome (RTT) is a rare neurodevelopmental disorder affecting almost exclusively females, caused in the overwhelming majority of the cases by loss-of-function mutations in the gene encoding methyl-CpG binding protein 2 (MECP2). High circulating levels of oxidative stress (OS) markers in patien...

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Bibliographic Details
Main Authors: Claudio De Felice, Floriana Della Ragione, Cinzia Signorini, Silvia Leoncini, Alessandra Pecorelli, Lucia Ciccoli, Francesco Scalabrì, Federico Marracino, Michele Madonna, Giuseppe Belmonte, Laura Ricceri, Bianca De Filippis, Giovanni Laviola, Giuseppe Valacchi, Thierry Durand, Jean-Marie Galano, Camille Oger, Alexandre Guy, Valérie Bultel-Poncé, Jacky Guy, Stefania Filosa, Joussef Hayek, Maurizio D'Esposito
Format: Article
Language:English
Published: Elsevier 2014-08-01
Series:Neurobiology of Disease
Subjects:
Rett syndrome
Lipid peroxidation
Brain damage
Neurodevelopmental disorder
Murine models
Oxidative stress
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996114000953

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http://www.sciencedirect.com/science/article/pii/S0969996114000953

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