The amyloid-beta forming tripeptide cleavage mechanism of γ-secretase

The amyloid-beta forming tripeptide cleavage mechanism of γ-secretase

γ-secretase is responsible for the proteolysis of amyloid precursor protein (APP) into short, aggregation-prone amyloid-beta (Aβ) peptides, which are centrally implicated in the pathogenesis of Alzheimer’s disease (AD). Despite considerable interest in developing γ-secretase targeting therapeutics f...

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Bibliographic Details
Main Authors: David M Bolduc, Daniel R Montagna, Matthew C Seghers, Michael S Wolfe, Dennis J Selkoe
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-08-01
Series:eLife
Subjects:
gamma-secretase
amyloid beta
intramembrane protease
Alzheimer's disease
Online Access:https://elifesciences.org/articles/17578

Internet

https://elifesciences.org/articles/17578

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