Systematic analysis of time-dependent neural effects of soluble amyloid β oligomers in culture and in vivo: Prevention by scyllo-inositol

by Ming Jin, Dennis J. Selkoe
Published 2015-10-01

LRP promotes endocytosis and degradation, but not transcytosis, of the amyloid-β peptide in a blood–brain barrier in vitro model

by Babak Nazer, Soyon Hong, Dennis J. Selkoe
Published 2008-04-01

Effects of prolonged angiotensin-converting enzyme inhibitor treatment on amyloid β-protein metabolism in mouse models of Alzheimer disease

by Matthew L. Hemming, Dennis J. Selkoe, Wesley Farris
Published 2007-04-01

Small non-fibrillar assemblies of amyloid β-protein bearing the Arctic mutation induce rapid neuritic degeneration

by Brian M. Whalen, Dennis J. Selkoe, Dean M. Hartley
Published 2005-11-01

Protofibrils of amyloid β-protein inhibit specific K+ currents in neocortical cultures

by Chian P Ye, Dennis J Selkoe, Dean M Hartley
Published 2003-08-01

Enriched environment enhances β‐adrenergic signaling to prevent microglia inflammation by amyloid‐β

by Huixin Xu, Molly M Rajsombath, Pia Weikop, Dennis J Selkoe
Published 2018-09-01

N-alpha-acetylation of α-synuclein increases its helical folding propensity, GM1 binding specificity and resistance to aggregation.

by Tim Bartels, Nora C Kim, Eric S Luth, Dennis J Selkoe
Published 2014-01-01

Cytosolic Phospholipase A2(cPLA2) Immunoreactivity Is Elevated in Alzheimer's Disease Brain

by Diane T. Stephenson, Cynthia A. Lemere, Dennis J. Selkoe, James A. Clemens
Published 1996-02-01

Receptor-Mediated Transport of Human Amyloid β-Protein 1–40 and 1–42 at the Blood–Brain Barrier

by Joseph F. Poduslo, Geoffry L. Curran, Bharati Sanyal, Dennis J. Selkoe
Published 1999-06-01

Identification of beta-secretase (BACE1) substrates using quantitative proteomics.

by Matthew L Hemming, Joshua E Elias, Steven P Gygi, Dennis J Selkoe
Published 2009-12-01

Proteomic profiling of gamma-secretase substrates and mapping of substrate requirements.

by Matthew L Hemming, Joshua E Elias, Steven P Gygi, Dennis J Selkoe
Published 2008-10-01

Soluble Aβ Oligomers Impair Dipolar Heterodendritic Plasticity by Activation of mGluR in the Hippocampal CA1 Region

by Jianhua Zhao, Anna Li, Molly Rajsombath, Yifan Dang, Dennis J. Selkoe, Shaomin Li
Published 2018-08-01

The amyloid-beta forming tripeptide cleavage mechanism of γ-secretase

by David M Bolduc, Daniel R Montagna, Matthew C Seghers, Michael S Wolfe, Dennis J Selkoe
Published 2016-08-01

Decoding the synaptic dysfunction of bioactive human AD brain soluble Aβ to inspire novel therapeutic avenues for Alzheimer’s disease

by Shaomin Li, Ming Jin, Lei Liu, Yifan Dang, Beth L. Ostaszewski, Dennis J. Selkoe
Published 2018-11-01

Reducing amyloid plaque burden via ex vivo gene delivery of an Abeta-degrading protease: a novel therapeutic approach to Alzheimer disease.

by Matthew L Hemming, Michaela Patterson, Casper Reske-Nielsen, Ling Lin, Ole Isacson, Dennis J Selkoe
Published 2007-08-01

Co-expression of β-amyloid precursor protein (βAPP) and apolipoprotein E in cell culture: analysis of βAPP processing

by Anja Leona Biere, Beth Ostaszewski, Hongwei Zhao, Susan Gillespie, Steven G. Younkin, Dennis J. Selkoe
Published 1995-06-01

Permeability and Residual Plasma Volume of Human, Dutch Variant, and Rat Amyloid β-Protein 1-40 at the Blood–Brain Barrier

by Joseph F. Poduslo, Geoffry L. Curran, Jill J. Haggard, Anja Leona Biere, Dennis J. Selkoe
Published 1997-01-01

Aggregation and catabolism of disease-associated intra-Aβ mutations: reduced proteolysis of AβA21G by neprilysin

by Vicki Betts, Malcolm A. Leissring, Georgia Dolios, Rong Wang, Dennis J. Selkoe, Dominic M. Walsh
Published 2008-09-01

FAD Mutations in Presenilin-1 or Amyloid Precursor Protein Decrease the Efficacy of a γ-Secretase Inhibitor: Evidence for Direct Involvement of PS1 in the γ-Secretase Cleavage Comp...

by Weiming Xia, Beth L. Ostaszewski, W.Taylor Kimberly, Talat Rahmati, Chad L. Moore, Michael S. Wolfe, Dennis J. Selkoe
Published 2000-12-01

Functional γ-secretase complex assembly in Golgi/trans-Golgi network: interactions among presenilin, nicastrin, Aph1, Pen-2, and γ-secretase substrates

by Stephanie Baulac, Matthew J LaVoie, W.Taylor Kimberly, Jennifer Strahle, Michael S Wolfe, Dennis J Selkoe, Weiming Xia
Published 2003-11-01