Synthetic Lethality Screening Highlights Colorectal Cancer Vulnerability to Concomitant Blockade of NEDD8 and EGFR Pathways

Synthetic Lethality Screening Highlights Colorectal Cancer Vulnerability to Concomitant Blockade of NEDD8 and EGFR Pathways

Colorectal cancer (CRC) is a heterogeneous disease showing significant variability in clinical aggressiveness. Primary and acquired resistance limits the efficacy of available treatments, and identification of effective drug combinations is needed to further improve patients’ outcomes. We previously...

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Bibliographic Details
Main Authors: Federica Invrea, Simona Punzi, Consalvo Petti, Rosalba Minelli, Michael D. Peoples, Christopher A. Bristow, Valentina Vurchio, Alessia Corrado, Alberto Bragoni, Caterina Marchiò, Andrea Bertotti, Livio Trusolino, Alberto Bardelli, Claudio Isella, Alessandro Carugo, Giulio F. Draetta, Enzo Medico
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Cancers
Subjects:
CRC
synthetic lethality screening
pevonedistat
NEDD8
EGFR pathway
Online Access:https://www.mdpi.com/2072-6694/13/15/3805

Internet

https://www.mdpi.com/2072-6694/13/15/3805

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