Rotenone induces degeneration of photoreceptors and impairs the dopaminergic system in the rat retina

Rotenone induces degeneration of photoreceptors and impairs the dopaminergic system in the rat retina

Rotenone is a widely used pesticide and a potent inhibitor of mitochondrial complex I (NADH-quinone reductase) that elicits the degeneration of dopaminergic neurons and thereby the appearance of a parkinsonian syndrome. Here we have addressed the alterations induced by rotenone at the functional, mo...

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Bibliographic Details
Main Authors: Julián Esteve-Rudd, Laura Fernández-Sánchez, Pedro Lax, Emilio De Juan, José Martín-Nieto, Nicolás Cuenca
Format: Article
Language:English
Published: Elsevier 2011-10-01
Series:Neurobiology of Disease
Subjects:
Retina
Parkinson disease
Rotenone
Retinal degeneration
Pesticide
Mitochondria
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996111002075

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http://www.sciencedirect.com/science/article/pii/S0969996111002075

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