Static and turnover kinetic measurement of protein biomarkers involved in triglyceride metabolism including apoB48 and apoA5 by LC/MS/MS[S]

Static and turnover kinetic measurement of protein biomarkers involved in triglyceride metabolism including apoB48 and apoA5 by LC/MS/MS[S]

LC/MS quantification of multiple plasma proteins that differ by several orders of magnitude in concentration from a single sample is challenging. We present a strategy that allows the simultaneous determination of the concentration and turnover kinetics of higher and lower abundant proteins from a s...

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Bibliographic Details
Main Authors: Yi Pan, Haihong Zhou, Ablatt Mahsut, Rory J. Rohm, Olga Berejnaia, Olga Price, Ying Chen, Jose Castro-Perez, Michael E. Lassman, David McLaren, James Conway, Kristian K. Jensen, Tiffany Thomas, Gissette Reyes-Soffer, Henry N. Ginsberg, David E. Gutstein, Michele Cleary, Stephen F. Previs, Thomas P. Roddy
Format: Article
Language:English
Published: Elsevier 2014-06-01
Series:Journal of Lipid Research
Subjects:
stable isotopes
mass spectrometry
kinetic biomarker
dyslipidemia
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520352810

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http://www.sciencedirect.com/science/article/pii/S0022227520352810

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