Targeting FGFR4 inhibits hepatocellular carcinoma in preclinical mouse models.

Targeting FGFR4 inhibits hepatocellular carcinoma in preclinical mouse models.

The fibroblast growth factor (FGF)-FGF receptor (FGFR) signaling system plays critical roles in a variety of normal developmental and physiological processes. It is also well documented that dysregulation of FGF-FGFR signaling may have important roles in tumor development and progression. The FGFR4-...

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Bibliographic Details
Main Authors: Dorothy M French, Benjamin C Lin, Manping Wang, Camellia Adams, Theresa Shek, Kathy Hötzel, Brad Bolon, Ronald Ferrando, Craig Blackmore, Kurt Schroeder, Luis A Rodriguez, Maria Hristopoulos, Rayna Venook, Avi Ashkenazi, Luc R Desnoyers
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3352934?pdf=render

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http://europepmc.org/articles/PMC3352934?pdf=render

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