Myeloid ATP Citrate Lyase Regulates Macrophage Inflammatory Responses In Vitro Without Altering Inflammatory Disease Outcomes

Myeloid ATP Citrate Lyase Regulates Macrophage Inflammatory Responses In Vitro Without Altering Inflammatory Disease Outcomes

Macrophages are highly plastic, key regulators of inflammation. Deregulation of macrophage activation can lead to excessive inflammation as seen in inflammatory disorders like atherosclerosis, obesity, multiple sclerosis and sepsis. Targeting intracellular metabolism is considered as an approach to...

Full description

Bibliographic Details
Main Authors: Sanne G. S. Verberk, Hendrik J. P. van der Zande, Jeroen Baardman, Kyra E. de Goede, Karl J. Harber, Eelco D. Keuning, Joost M. Lambooij, Frank Otto, Anna Zawistowska-Deniziak, Helga E. de Vries, Menno P. J. de Winther, Bruno Guigas, Jan Van den Bossche
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Immunology
Subjects:
obesity
peritonitis
macrophage
immunometabolism
inflammation
ATP citrate lyase
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.669920/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.669920/full

Similar Items