Microglial activation contributes to cognitive impairments in rotenone-induced mouse Parkinson’s disease model

Microglial activation contributes to cognitive impairments in rotenone-induced mouse Parkinson’s disease model

Abstract Background Cognitive decline occurs frequently in Parkinson’s disease (PD), which greatly decreases the quality of life of patients. However, the mechanisms remain to be investigated. Neuroinflammation mediated by overactivated microglia is a common pathological feature in multiple neurolog...

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Bibliographic Details
Main Authors: Dongdong Zhang, Sheng Li, Liyan Hou, Lu Jing, Zhengzheng Ruan, Bingjie Peng, Xiaomeng Zhang, Jau-Shyong Hong, Jie Zhao, Qingshan Wang
Format: Article
Language:English
Published: BMC 2021-01-01
Series:Journal of Neuroinflammation
Subjects:
Neuroinflammation
Apoptosis
Microglial depletion
Cognitive deficits
Parkinson’s disease
Online Access:https://doi.org/10.1186/s12974-020-02065-z

Internet

https://doi.org/10.1186/s12974-020-02065-z

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