High content analysis identifies unique morphological features of reprogrammed cardiomyocytes

Abstract Direct reprogramming of fibroblasts into cardiomyocytes is a promising approach for cardiac regeneration but still faces challenges in efficiently generating mature cardiomyocytes. Systematic optimization of reprogramming protocols requires scalable, objective methods to assess cellular phe...

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Bibliographic Details
Main Authors: Matthew D. Sutcliffe, Philip M. Tan, Antonio Fernandez-Perez, Young-Jae Nam, Nikhil V. Munshi, Jeffrey J. Saucerman
Format: Article
Language:English
Published: Nature Publishing Group 2018-01-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-018-19539-z