Trans-ancestry Fine Mapping and Molecular Assays Identify Regulatory Variants at the ANGPTL8 HDL-C GWAS Locus

Trans-ancestry Fine Mapping and Molecular Assays Identify Regulatory Variants at the ANGPTL8 HDL-C GWAS Locus

Recent genome-wide association studies (GWAS) have identified variants associated with high-density lipoprotein cholesterol (HDL-C) located in or near the ANGPTL8 gene. Given the extensive sharing of GWAS loci across populations, we hypothesized that at least one shared variant at this locus affects...

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Bibliographic Details
Main Authors: Maren E. Cannon, Qing Duan, Ying Wu, Monica Zeynalzadeh, Zheng Xu, Antti J. Kangas, Pasi Soininen, Mika Ala-Korpela, Mete Civelek, Aldons J. Lusis, Johanna Kuusisto, Francis S. Collins, Michael Boehnke, Hua Tang, Markku Laakso, Yun Li, Karen L. Mohlke
Format: Article
Language:English
Published: Oxford University Press 2017-09-01
Series:G3: Genes, Genomes, Genetics
Subjects:
Genetics
Gene Expression
Cholesterol
Transcription
Complex genetic traits
Online Access:http://g3journal.org/lookup/doi/10.1534/g3.117.300088

Internet

http://g3journal.org/lookup/doi/10.1534/g3.117.300088

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