The metabolic enzyme arginase-2 is a potential target for novel immune modulatory vaccines

The metabolic enzyme arginase-2 is a potential target for novel immune modulatory vaccines

One way that tumors evade immune destruction is through tumor and stromal cell expression of arginine-degrading enzyme arginase-2 (ARG2). Here we describe the existence of pro-inflammatory effector T-cells that recognize ARG2 and can directly target tumor and tumor-infiltrating cells. Using a librar...

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Bibliographic Details
Main Authors: Stine Emilie Weis-Banke, Mie Linder Hübbe, Morten Orebo Holmström, Mia Aaboe Jørgensen, Simone Kloch Bendtsen, Evelina Martinenaite, Marco Carretta, Inge Marie Svane, Niels Ødum, Ayako Wakatsuki Pedersen, Özcan Met, Daniel Hargbøl Madsen, Mads Hald Andersen
Format: Article
Language:English
Published: Taylor & Francis Group 2020-01-01
Series:OncoImmunology
Subjects:
anti-tregs
arg2
immune modulation
t-win
Online Access:http://dx.doi.org/10.1080/2162402X.2020.1771142

Internet

http://dx.doi.org/10.1080/2162402X.2020.1771142

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