T-Cell Gene Therapy in Cancer Immunotherapy: Why It Is No Longer Just CARs on The Road

by Michael D. Crowther, Inge Marie Svane, Özcan Met
Published 2020-06-01

ACT Up TIL Now: The Evolution of Tumor-Infiltrating Lymphocytes in Adoptive Cell Therapy for the Treatment of Solid Tumors

by Thomas Morgan Hulen, Christopher Aled Chamberlain, Inge Marie Svane, Özcan Met
Published 2021-07-01

Vγ9Vδ2 T Cells Concurrently Kill Cancer Cells and Cross-Present Tumor Antigens

by Gitte Holmen Olofsson, Manja Idorn, Manja Idorn, Ana Micaela Carnaz Simões, Pia Aehnlich, Signe Koggersbøl Skadborg, Elfriede Noessner, Reno Debets, Bernhard Moser, Özcan Met, Özcan Met, Per thor Straten, Per thor Straten
Published 2021-06-01

Chemokine receptor engineering of T cells with CXCR2 improves homing towards subcutaneous human melanomas in xenograft mouse model

by Manja Idorn, Signe Koggersbøl Skadborg, Lauge Kellermann, Hólmfrídur Rósa Halldórsdóttir, Gitte Holmen Olofsson, Özcan Met, Per thor Straten
Published 2018-08-01

Improved migration of tumor ascites lymphocytes to ovarian cancer microenvironment by CXCR2 transduction

by Manja Idorn, Maria Olsen, Hólmfrídur Rósa Halldórsdóttir, Signe Koggersbøl Skadborg, Magnus Pedersen, Claus Høgdall, Estrid Høgdall, Özcan Met, Per thor Straten
Published 2018-04-01

Peptide Vaccination Against PD-L1 With IO103 a Novel Immune Modulatory Vaccine in Multiple Myeloma: A Phase I First-in-Human Trial

by Nicolai Grønne Jørgensen, Nicolai Grønne Jørgensen, Uffe Klausen, Uffe Klausen, Jacob Handlos Grauslund, Carsten Helleberg, Thomas Granum Aagaard, Trung Hieu Do, Shamaila Munir Ahmad, Lars Rønn Olsen, Tobias Wirenfeldt Klausen, Marie Fredslund Breinholt, Morten Hansen, Evelina Martinenaite, Özcan Met, Özcan Met, Inge Marie Svane, Lene Meldgaard Knudsen, Mads Hald Andersen, Mads Hald Andersen
Published 2020-11-01

Inflammation induced PD-L1-specific T cells

by Shamaila Munir, Mia Thorup Lundsager, Mia Aabroe Jørgensen, Morten Hansen, Trine Hilkjær Petersen, Charlotte Menne Bonefeld, Christina Friese, Özcan Met, Per thor Straten, Mads Hald Andersen
Published 2019-09-01

Vaccination against PD-L1 with IO103 a Novel Immune Modulatory Vaccine in Basal Cell Carcinoma: A Phase IIa Study

by Nicolai Grønne Jørgensen, Jeanette Kaae, Jacob Handlos Grauslund, Özcan Met, Signe Ledou Nielsen, Ayako Wakatsuki Pedersen, Inge Marie Svane, Eva Ehrnrooth, Mads Hald Andersen, Claus Zachariae, Lone Skov
Published 2021-02-01

T cell recognition of novel shared breast cancer antigens is frequently observed in peripheral blood of breast cancer patients

by Nadia Viborg, Sofie Ramskov, Rikke Sick Andersen, Theo Sturm, Tim Fugmann, Amalie Kai Bentzen, Vibeke Mindahl Rafa, Per thor Straten, Inge Marie Svane, Özcan Met, Sine Reker Hadrup
Published 2019-12-01

Frequent adaptive immune responses against arginase-1

by Evelina Martinenaite, Rasmus Erik Johansson Mortensen, Morten Hansen, Morten Orebo Holmström, Shamaila Munir Ahmad, Nicolai Grønne Dahlager Jørgensen, Özcan Met, Marco Donia, Inge Marie Svane, Mads Hald Andersen
Published 2018-03-01

Therapeutic Cancer Vaccination With a Peptide Derived From the Calreticulin Exon 9 Mutations Induces Strong Cellular Immune Responses in Patients With CALR-Mutant Chronic Myeloprol...

by Jacob Handlos Grauslund, Morten Orebo Holmström, Nicolai Grønne Jørgensen, Uffe Klausen, Stine Emilie Weis-Banke, Daniel El Fassi, Daniel El Fassi, Claudia Schöllkopf, Mette Borg Clausen, Lise Mette Rahbek Gjerdrum, Marie Fredslund Breinholt, Julie Westerlin Kjeldsen, Morten Hansen, Steffen Koschmieder, Nicolas Chatain, Guy Wayne Novotny, Jesper Petersen, Lasse Kjær, Vibe Skov, Özcan Met, Özcan Met, Inge Marie Svane, Hans Carl Hasselbalch, Mads Hald Andersen, Mads Hald Andersen
Published 2021-02-01

The inhibitory checkpoint, PD-L2, is a target for effector T cells: Novel possibilities for immune therapy

by Shamaila Munir Ahmad, Evelina Martinenaite, Morten Holmström, Mia Aaboe Jørgensen, Özcan Met, Claudia Nastasi, Uffe Klausen, Marco Donia, Lars Møller Pedersen, Lars Munksgaard, Niels Ødum, Anders Woetmann, Inge Marie Svane, Mads Hald Andersen
Published 2018-02-01

The metabolic enzyme arginase-2 is a potential target for novel immune modulatory vaccines

by Stine Emilie Weis-Banke, Mie Linder Hübbe, Morten Orebo Holmström, Mia Aaboe Jørgensen, Simone Kloch Bendtsen, Evelina Martinenaite, Marco Carretta, Inge Marie Svane, Niels Ødum, Ayako Wakatsuki Pedersen, Özcan Met, Daniel Hargbøl Madsen, Mads Hald Andersen
Published 2020-01-01

Clinical efficacy of T-cell therapy after short-term BRAF-inhibitor priming in patients with checkpoint inhibitor-resistant metastatic melanoma

by Marco Donia, Rikke Andersen, Troels Holz Borch, Per Kongsted, Özcan Met, Julie Westerlin Kjeldsen, Morten Nielsen, Magnus Pedersen, Martin Lauss, Göran Jönsson, Inge Marie Svane, Katja Harbst, Aynal Haque Rana, Evelina Martinenaite, Anders Handrup Kverneland, Lisbet Rosenkrantz Hölmich, Helle Hendel
Published 2021-07-01

Adoptive cell therapy with tumor-infiltrating lymphocytes in patients with metastatic ovarian cancer: a pilot study

by Magnus Pedersen, Marie Christine Wulff Westergaard, Katy Milne, Morten Nielsen, Troels Holz Borch, Lars Grønlund Poulsen, Helle Westergren Hendel, Mia Kennedy, Gillian Briggs, Stacey Ledoux, Trine Jakobi Nøttrup, Pernille Andersen, Thomas Hasselager, Özcan Met, Brad H. Nelson, Marco Donia, Inge Marie Svane
Published 2018-12-01

Qualitative Analysis of Tumor-Infiltrating Lymphocytes across Human Tumor Types Reveals a Higher Proportion of Bystander CD8⁺ T Cells in Non-Melanoma Cancers Compared to...

by Aishwarya Gokuldass, Arianna Draghi, Krisztian Papp, Troels Holz Borch, Morten Nielsen, Marie Christine Wulff Westergaard, Rikke Andersen, Aimilia Schina, Kalijn Fredrike Bol, Christopher Aled Chamberlain, Mario Presti, Özcan Met, Katja Harbst, Martin Lauss, Samuele Soraggi, Istvan Csabai, Zoltán Szállási, Göran Jönsson, Inge Marie Svane, Marco Donia
Published 2020-11-01

An immunogenic first-in-human immune modulatory vaccine with PD-L1 and PD-L2 peptides is feasible and shows early signs of efficacy in follicular lymphoma

by Uffe Klausen, Nicolai Grønne Dahlager Jørgensen, Jacob Handlos Grauslund, Shamaila Munir Ahmad, Anne Ortved Gang, Evelina Martinenaite, Stine Emilie Weis-Banke, Marie Fredslund Breinholt, Guy Wayne Novotny, Julie Westerlin Kjeldsen, Morten Orebo Holmström, Lone Bredo Pedersen, Christian Bjørn Poulsen, Per Boye Hansen, Özcan Met, Inge Marie Svane, Carsten Utoft Niemann, Lars Møller Pedersen, Mads Hald Andersen
Published 2021-01-01