Inhibition of phosphoenolpyruvate carboxykinase blocks lactate utilization and impairs tumor growth in colorectal cancer

Inhibition of phosphoenolpyruvate carboxykinase blocks lactate utilization and impairs tumor growth in colorectal cancer

Abstract Background Metabolic reprogramming is a key feature of malignant cells. While glucose is one of the primary substrates for malignant cells, cancer cells also display a remarkable metabolic flexibility. Depending on nutrient availability and requirements, cancer cells will utilize alternativ...

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Bibliographic Details
Main Authors: Emily D. Montal, Kavita Bhalla, Ruby E. Dewi, Christian F. Ruiz, John A. Haley, Ashley E. Ropell, Chris Gordon, John D. Haley, Geoffrey D. Girnun
Format: Article
Language:English
Published: BMC 2019-08-01
Series:Cancer & Metabolism
Subjects:
Lactate
Cancer metabolism
PEPCK
Metabolic flexibility
TCA cycle
Online Access:http://link.springer.com/article/10.1186/s40170-019-0199-6

Internet

http://link.springer.com/article/10.1186/s40170-019-0199-6

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