Synaptic FUS accumulation triggers early misregulation of synaptic RNAs in a mouse model of ALS
Mutations in the RNA-binding protein FUS contribute to ALS. Here the authors use CLIP-seq on synaptoneurosomes to identify proteins associated with synapse organization and plasticity that are differentially regulated in a knock-in ALS mouse model.
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2021-05-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-23188-8 |
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doaj-e9c043534e61495b8e1dfb249245ca1e2021-05-23T11:12:57ZengNature Publishing GroupNature Communications2041-17232021-05-0112111710.1038/s41467-021-23188-8Synaptic FUS accumulation triggers early misregulation of synaptic RNAs in a mouse model of ALSSonu Sahadevan0Katharina M. Hembach1Elena Tantardini2Manuela Pérez-Berlanga3Marian Hruska-Plochan4Salim Megat5Julien Weber6Petra Schwarz7Luc Dupuis8Mark D. Robinson9Pierre De Rossi10Magdalini Polymenidou11Department of Quantitative Biomedicine, University of ZurichDepartment of Quantitative Biomedicine, University of ZurichDepartment of Quantitative Biomedicine, University of ZurichDepartment of Quantitative Biomedicine, University of ZurichDepartment of Quantitative Biomedicine, University of ZurichInserm, University of StrasbourgDepartment of Quantitative Biomedicine, University of ZurichInstitute of Neuropathology, University Hospital ZurichInserm, University of StrasbourgDepartment of Molecular Life Sciences and SIB Swiss Institute of Bioinformatics, University of ZurichDepartment of Quantitative Biomedicine, University of ZurichDepartment of Quantitative Biomedicine, University of ZurichMutations in the RNA-binding protein FUS contribute to ALS. Here the authors use CLIP-seq on synaptoneurosomes to identify proteins associated with synapse organization and plasticity that are differentially regulated in a knock-in ALS mouse model.https://doi.org/10.1038/s41467-021-23188-8 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Sonu Sahadevan Katharina M. Hembach Elena Tantardini Manuela Pérez-Berlanga Marian Hruska-Plochan Salim Megat Julien Weber Petra Schwarz Luc Dupuis Mark D. Robinson Pierre De Rossi Magdalini Polymenidou |
| spellingShingle |
Sonu Sahadevan Katharina M. Hembach Elena Tantardini Manuela Pérez-Berlanga Marian Hruska-Plochan Salim Megat Julien Weber Petra Schwarz Luc Dupuis Mark D. Robinson Pierre De Rossi Magdalini Polymenidou Synaptic FUS accumulation triggers early misregulation of synaptic RNAs in a mouse model of ALS Nature Communications |
| author_facet |
Sonu Sahadevan Katharina M. Hembach Elena Tantardini Manuela Pérez-Berlanga Marian Hruska-Plochan Salim Megat Julien Weber Petra Schwarz Luc Dupuis Mark D. Robinson Pierre De Rossi Magdalini Polymenidou |
| author_sort |
Sonu Sahadevan |
| title |
Synaptic FUS accumulation triggers early misregulation of synaptic RNAs in a mouse model of ALS |
| title_short |
Synaptic FUS accumulation triggers early misregulation of synaptic RNAs in a mouse model of ALS |
| title_full |
Synaptic FUS accumulation triggers early misregulation of synaptic RNAs in a mouse model of ALS |
| title_fullStr |
Synaptic FUS accumulation triggers early misregulation of synaptic RNAs in a mouse model of ALS |
| title_full_unstemmed |
Synaptic FUS accumulation triggers early misregulation of synaptic RNAs in a mouse model of ALS |
| title_sort |
synaptic fus accumulation triggers early misregulation of synaptic rnas in a mouse model of als |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2021-05-01 |
| description |
Mutations in the RNA-binding protein FUS contribute to ALS. Here the authors use CLIP-seq on synaptoneurosomes to identify proteins associated with synapse organization and plasticity that are differentially regulated in a knock-in ALS mouse model. |
| url |
https://doi.org/10.1038/s41467-021-23188-8 |
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