Synaptic FUS accumulation triggers early misregulation of synaptic RNAs in a mouse model of ALS

Synaptic FUS accumulation triggers early misregulation of synaptic RNAs in a mouse model of ALS

Mutations in the RNA-binding protein FUS contribute to ALS. Here the authors use CLIP-seq on synaptoneurosomes to identify proteins associated with synapse organization and plasticity that are differentially regulated in a knock-in ALS mouse model.

Bibliographic Details
Main Authors: Sonu Sahadevan, Katharina M. Hembach, Elena Tantardini, Manuela Pérez-Berlanga, Marian Hruska-Plochan, Salim Megat, Julien Weber, Petra Schwarz, Luc Dupuis, Mark D. Robinson, Pierre De Rossi, Magdalini Polymenidou
Format: Article
Language:English
Published: Nature Publishing Group 2021-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-23188-8

Internet

https://doi.org/10.1038/s41467-021-23188-8

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