Mapping DNA sequence to transcription factor binding energy in vivo.

Despite the central importance of transcriptional regulation in biology, it has proven difficult to determine the regulatory mechanisms of individual genes, let alone entire gene networks. It is particularly difficult to decipher the biophysical mechanisms of transcriptional regulation in living cel...

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Bibliographic Details
Main Authors: Stephanie L Barnes, Nathan M Belliveau, William T Ireland, Justin B Kinney, Rob Phillips
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-02-01
Series:PLoS Computational Biology
Online Access:https://doi.org/10.1371/journal.pcbi.1006226