Centrin-Deleted Leishmania donovani Parasites Help CD4+ T Cells to Acquire Th1 Phenotype and Multi-Functionality Through Downregulation of CD200–CD200R Immune Inhibitory Axis

Centrin-Deleted Leishmania donovani Parasites Help CD4+ T Cells to Acquire Th1 Phenotype and Multi-Functionality Through Downregulation of CD200–CD200R Immune Inhibitory Axis

The protozoan parasite Leishmania has evolved several strategies to undermine host defense mechanisms by inducing Th2-type adaptive immunity and suppressing effector functions of Th1 phenotype. In our earlier studies, using centrin gene-deleted Leishmania (LdCen−/−) parasites as an immunogen, we hav...

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Bibliographic Details
Main Authors: Rakesh K. Singh, Sreenivas Gannavaram, Nevien Ismail, Amit Kaul, Mallikarjuna Rao Gedda, Hira L. Nakhasi
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-06-01
Series:Frontiers in Immunology
Subjects:
CD-200
CD200-R
live attenuated vaccines
Leishmania
vaccine immunity
multi-functionality
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01176/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.01176/full

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