Immunization with Live Attenuated Leishmania donovani Centrin−/− Parasites Is Efficacious in Asymptomatic Infection

by Nevien Ismail, Amit Kaul, Parna Bhattacharya, Sreenivas Gannavaram, Hira L. Nakhasi
Published 2017-12-01

Deletion of ubiquitin fold modifier protein Ufm1 processing peptidase Ufsp in L. donovani abolishes Ufm1 processing and alters pathogenesis.

by Sreenivas Gannavaram, Sonya Davey, Ines Lakhal-Naouar, Robert Duncan, Hira L Nakhasi
Published 2014-02-01

Mitochondrial associated ubiquitin fold modifier-1 mediated protein conjugation in Leishmania donovani.

by Sreenivas Gannavaram, Paresh Sharma, Robert C Duncan, Poonam Salotra, Hira L Nakhasi
Published 2011-01-01

miR-21 Expression Determines the Early Vaccine Immunity Induced by LdCen−/− Immunization

by Sreenivas Gannavaram, Parna Bhattacharya, Abid Siddiqui, Nevien Ismail, Subha Madhavan, Hira L. Nakhasi
Published 2019-09-01

Whole genome sequencing of live attenuated Leishmania donovani parasites reveals novel biomarkers of attenuation and enables product characterization

by Sreenivas Gannavaram, John Torcivia, Lusine Gasparyan, Amit Kaul, Nevien Ismail, Vahan Simonyan, Hira L. Nakhasi
Published 2017-07-01

Immunity to Visceral Leishmaniasis Using Genetically Defined Live-Attenuated Parasites

by Angamuthu Selvapandiyan, Ranadhir Dey, Sreenivas Gannavaram, Ines Lakhal-Naouar, Robert Duncan, Poonam Salotra, Hira L. Nakhasi
Published 2012-01-01

Revival of Leishmanization and Leishmanin

by Thalia Pacheco-Fernandez, Greta Volpedo, Sreenivas Gannavaram, Parna Bhattacharya, Ranadhir Dey, Abhay Satoskar, Greg Matlashewski, Hira L. Nakhasi
Published 2021-03-01

Centrin-Deleted Leishmania donovani Parasites Help CD4+ T Cells to Acquire Th1 Phenotype and Multi-Functionality Through Downregulation of CD200–CD200R Immune Inhibitory Axis

by Rakesh K. Singh, Rakesh K. Singh, Sreenivas Gannavaram, Nevien Ismail, Amit Kaul, Amit Kaul, Mallikarjuna Rao Gedda, Hira L. Nakhasi
Published 2018-06-01

Intradermal Immunization of Leishmania donovani Centrin Knock-Out Parasites in Combination with Salivary Protein LJM19 from Sand Fly Vector Induces a Durable Protective Immune Resp...

by Jacqueline Araújo Fiuza, Ranadhir Dey, Dwann Davenport, Maha Abdeladhim, Claudio Meneses, Fabiano Oliveira, Shaden Kamhawi, Jesus G Valenzuela, Sreenivas Gannavaram, Hira L Nakhasi
Published 2016-01-01

Live Attenuated Leishmania donovani Centrin Knock Out Parasites Generate Non-inferior Protective Immune Response in Aged Mice against Visceral Leishmaniasis.

by Parna Bhattacharya, Ranadhir Dey, Pradeep K Dagur, Amritanshu B Joshi, Nevien Ismail, Sreenivas Gannavaram, Alain Debrabant, Adovi D Akue, Mark A KuKuruga, Angamuthu Selvapandiyan, John Philip McCoy, Hira L Nakhasi
Published 2016-08-01

Preclinical validation of a live attenuated dermotropic Leishmania vaccine against vector transmitted fatal visceral leishmaniasis

by Subir Karmakar, Nevien Ismail, Fabiano Oliveira, James Oristian, Wen Wei Zhang, Swarnendu Kaviraj, Kamaleshwar P. Singh, Abhishek Mondal, Sushmita Das, Krishna Pandey, Parna Bhattacharya, Greta Volpedo, Sreenivas Gannavaram, Monika Satoskar, Sanika Satoskar, Rajiv M. Sastry, Timur Oljuskin, Telly Sepahpour, Claudio Meneses, Shinjiro Hamano, Pradeep Das, Greg Matlashewski, Sanjay Singh, Shaden Kamhawi, Ranadhir Dey, Jesus G. Valenzuela, Abhay Satoskar, Hira L. Nakhasi
Published 2021-07-01

A second generation leishmanization vaccine with a markerless attenuated Leishmania major strain using CRISPR gene editing

by Wen-Wei Zhang, Subir Karmakar, Sreenivas Gannavaram, Ranadhir Dey, Patrick Lypaczewski, Nevien Ismail, Abid Siddiqui, Vahan Simonyan, Fabiano Oliveira, Iliano V. Coutinho-Abreu, Thiago DeSouza-Vieira, Claudio Meneses, James Oristian, Tiago D. Serafim, Abu Musa, Risa Nakamura, Noushin Saljoughian, Greta Volpedo, Monika Satoskar, Sanika Satoskar, Pradeep K. Dagur, J. Philip McCoy, Shaden Kamhawi, Jesus G. Valenzuela, Shinjiro Hamano, Abhay R. Satoskar, Greg Matlashewski, Hira L. Nakhasi
Published 2020-07-01