Immunomodulatory factors galectin-9 and interferon-gamma synergize to induce expression of rate-limiting enzymes of the Kynurenine Pathway in the mouse hippocampus

Immunomodulatory factors galectin-9 and interferon-gamma synergize to induce expression of rate-limiting enzymes of the Kynurenine Pathway in the mouse hippocampus

Elevated levels of circulating pro-inflammatory cytokines are associated with symptomology of several psychiatric disorders, notably major depressive disorder. Symptomology has been linked to inflammation/cytokine-dependent induction of the Kynurenine Pathway. Galectins, like pro-inflammatory cytoki...

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Bibliographic Details
Main Authors: Alexandra K Brooks, Marcus A Lawson, Jennifer L Rytych, Kevin C Yu, Tiffany M Janda, Andrew J Steelman, Robert H McCusker
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-10-01
Series:Frontiers in Immunology
Subjects:
IFNγ
IDO1
kynurenine pathway
Neuroinflammation; Cytokines
galectin 9
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00422/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00422/full

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