Derivatives of the β-Crinane Amaryllidaceae Alkaloid Haemanthamine as Multi-Target Directed Ligands for Alzheimer’s Disease

Derivatives of the β-Crinane Amaryllidaceae Alkaloid Haemanthamine as Multi-Target Directed Ligands for Alzheimer’s Disease

Twelve derivatives <b>1a</b>&#8211;<b>1m</b> of the &#946;-crinane-type alkaloid haemanthamine were developed. All the semisynthetic derivatives were studied for their inhibitory potential against both acetylcholinesterase and butyrylcholinesterase. In addition, glyco...

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Bibliographic Details
Main Authors: Eliška Kohelová, Rozálie Peřinová, Negar Maafi, Jan Korábečný, Daniela Hulcová, Jana Maříková, Tomáš Kučera, Loreto Martínez González, Martina Hrabinova, Katarina Vorčáková, Lucie Nováková, Angela De Simone, Radim Havelek, Lucie Cahlíková
Format: Article
Language:English
Published: MDPI AG 2019-04-01
Series:Molecules
Subjects:
haemanthamine
Amaryllidaceae
Alzheimer’s disease
acetylcholinesterase
butyrylcholinesterase
glycogen synthase kinase-3β inhibition
docking studies
Online Access:https://www.mdpi.com/1420-3049/24/7/1307

Internet

https://www.mdpi.com/1420-3049/24/7/1307

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