The Succinated Proteome of FH-Mutant Tumours

The Succinated Proteome of FH-Mutant Tumours

Inherited mutations in the Krebs cycle enzyme fumarate hydratase (FH) predispose to hereditary leiomyomatosis and renal cell cancer (HLRCC). Loss of FH activity in HLRCC tumours causes accumulation of the Krebs cycle intermediate fumarate to high levels, which may act as an oncometabolite through va...

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Bibliographic Details
Main Authors: Ming Yang, Nicola Ternette, Huizhong Su, Raliat Dabiri, Benedikt M. Kessler, Julie Adam, Bin Tean Teh, Patrick J. Pollard
Format: Article
Language:English
Published: MDPI AG 2014-08-01
Series:Metabolites
Subjects:
fumarate hydratase
succination
cysteine
renal cancer
hereditary leiomyomatosis and renal cell cancer (HLRCC)
oncometabolite
biomarker
reactive oxygen species (ROS)
Online Access:http://www.mdpi.com/2218-1989/4/3/640

Internet

http://www.mdpi.com/2218-1989/4/3/640

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