Inhibiting glucosylceramide synthase exacerbates cisplatin-induced acute kidney injury

Inhibiting glucosylceramide synthase exacerbates cisplatin-induced acute kidney injury

Acute kidney injury (AKI), resulting from chemotherapeutic agents such as cisplatin, remains an obstacle in the treatment of cancer. Cisplatin-induced AKI involves apoptotic and necrotic cell death, pathways regulated by sphingolipids such as ceramide and glucosylceramide. Results from this study in...

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Bibliographic Details
Main Authors: Tess V. Dupre, Mark A. Doll, Parag P. Shah, Cierra N. Sharp, Deanna Siow, Judit Megyesi, James Shayman, Alicja Bielawska, Jacek Bielawski, Levi J. Beverly, Maria Hernandez-Corbacho, Christopher J. Clarke, Ashley J. Snider, Rick G. Schnellmann, Lina M. Obeid, Yusuf A. Hannun, Leah J. Siskind
Format: Article
Language:English
Published: Elsevier 2017-07-01
Series:Journal of Lipid Research
Subjects:
ceramide
sphingolipids
apoptosis
inflammation
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520335938

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http://www.sciencedirect.com/science/article/pii/S0022227520335938

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