The Transcription Factor T-Bet Is Required for Optimal Type I Follicular Helper T Cell Maintenance During Acute Viral Infection

The Transcription Factor T-Bet Is Required for Optimal Type I Follicular Helper T Cell Maintenance During Acute Viral Infection

Follicular helper T cells (TFH cells), known as the primary “helpers” of the germinal center (GC) reaction, promote the humoral immune response to defend against various pathogens. Under conditions of infection by different types of pathogens, many shared transcription factors (TFs), such as Bcl-6,...

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Bibliographic Details
Main Authors: Pengcheng Wang, Youping Wang, Luoyingzi Xie, Minglu Xiao, Jialin Wu, Lifan Xu, Qiang Bai, Yaxing Hao, Qizhao Huang, Xiangyu Chen, Ran He, Baohua Li, Sen Yang, Yaokai Chen, Yuzhang Wu, Lilin Ye
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Immunology
Subjects:
T-bet
follicular helper T cells
type I immune response
humoral response
T cell differentiation
transcriptional regulation
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00606/full

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https://www.frontiersin.org/article/10.3389/fimmu.2019.00606/full

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