Why do mutant allele frequencies in oncogenes peak around .40 and rapidly decrease?
The mutant allele frequencies in oncogenes peak around .40 and rapidly decrease. In this article, we explain why this is the case. Invoking a key result from mathematical analysis in our model, namely, the inverse function theorem, we estimate the selection coefficients of the mutant alleles as a fu...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Intercollegiate Biomathematics Alliance
2016-01-01
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| Series: | Letters in Biomathematics |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/23737867.2016.1221328 |