Inhibiting WNT and NOTCH in renal cancer stem cells and the implications for human patients
Cancer stem cells are thought to be largely resistant to treatment and can be responsible for tumour recurrence. Here, using renal cancer organoids, self-renewing sphere cultures and PDX from patients, the authors show that the proliferation of stem cells within organoids, PDX and spheres can be blo...
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2020-02-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-14700-7 |