Two different pathogenic mechanisms, dying-back axonal neuropathy and pancreatic senescence, are present in the YG8R mouse model of Friedreich’s ataxia

Two different pathogenic mechanisms, dying-back axonal neuropathy and pancreatic senescence, are present in the YG8R mouse model of Friedreich’s ataxia

Frataxin (FXN) deficiency causes Friedreich’s ataxia (FRDA), a multisystem disorder with neurological and non-neurological symptoms. FRDA pathophysiology combines developmental and degenerative processes of dorsal root ganglia (DRG), sensory nerves, dorsal columns and other central nervous structure...

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Bibliographic Details
Main Authors: Belén Mollá, Fátima Riveiro, Arantxa Bolinches-Amorós, Diana C. Muñoz-Lasso, Francesc Palau, Pilar González-Cabo
Format: Article
Language:English
Published: The Company of Biologists 2016-06-01
Series:Disease Models & Mechanisms
Subjects:
Friedreich’s ataxia
Dying-back neuropathy
Dorsal root ganglia
Muscle spindle
Cell senescence
Islet of Langerhans
Online Access:http://dmm.biologists.org/content/9/6/647

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http://dmm.biologists.org/content/9/6/647

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