Hexokinases link DJ-1 to the PINK1/parkin pathway

Hexokinases link DJ-1 to the PINK1/parkin pathway

Abstract Background Early onset Parkinson’s disease is caused by variants in PINK1, parkin, and DJ-1. PINK1 and parkin operate in pathways that preserve mitochondrial integrity, but the function of DJ-1 and how it relates to PINK1 and parkin is poorly understood. Methods A series of unbiased high-co...

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Bibliographic Details
Main Authors: David N. Hauser, Adamantios Mamais, Melissa M. Conti, Christopher T. Primiani, Ravindran Kumaran, Allissa A. Dillman, Rebekah G. Langston, Alexandra Beilina, Joseph H. Garcia, Alberto Diaz-Ruiz, Michel Bernier, Fabienne C. Fiesel, Xu Hou, Wolfdieter Springer, Yan Li, Rafael de Cabo, Mark R. Cookson
Format: Article
Language:English
Published: BMC 2017-09-01
Series:Molecular Neurodegeneration
Subjects:
Proteomics
RNA-Seq
Metabolomics
Systems biology
Parkinson’s disease
Mitophagy
Online Access:http://link.springer.com/article/10.1186/s13024-017-0212-x

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http://link.springer.com/article/10.1186/s13024-017-0212-x

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