Phosphorylation by PINK1 releases the UBL domain and initializes the conformational opening of the E3 ubiquitin ligase Parkin.

by Thomas R Caulfield, Fabienne C Fiesel, Elisabeth L Moussaud-Lamodière, Daniel F A R Dourado, Samuel C Flores, Wolfdieter Springer
Published 2014-11-01

TDP-43-mediated neuron loss in vivo requires RNA-binding activity.

by Aaron Voigt, David Herholz, Fabienne C Fiesel, Kavita Kaur, Daniel Müller, Peter Karsten, Stephanie S Weber, Philipp J Kahle, Till Marquardt, Jörg B Schulz
Published 2010-01-01

Alpha-synuclein-induced mitochondrial dysfunction is mediated via a sirtuin 3-dependent pathway

by Jae-Hyeon Park, Jeremy D. Burgess, Ayman H. Faroqi, Natasha N. DeMeo, Fabienne C. Fiesel, Wolfdieter Springer, Marion Delenclos, Pamela J. McLean
Published 2020-01-01

Early-Onset Parkinson Disease Screening in Patients From Nigeria

by Lukasz M. Milanowski, Lukasz M. Milanowski, Olajumoke Oshinaike, Benjamin J. Broadway, Jennifer A. Lindemann, Alexandra I. Soto-Beasley, Ronald L. Walton, Rana Hanna Al-Shaikh, Audrey J. Strongosky, Fabienne C. Fiesel, Fabienne C. Fiesel, Owen A. Ross, Owen A. Ross, Owen A. Ross, Wolfdieter Springer, Wolfdieter Springer, Shamsideen Abayomi Ogun, Zbigniew K. Wszolek
Published 2021-01-01

The PINK1 p.I368N mutation affects protein stability and ubiquitin kinase activity

by Maya Ando, Fabienne C. Fiesel, Roman Hudec, Thomas R. Caulfield, Kotaro Ogaki, Paulina Górka-Skoczylas, Dariusz Koziorowski, Andrzej Friedman, Li Chen, Valina L. Dawson, Ted M. Dawson, Guojun Bu, Owen A. Ross, Zbigniew K. Wszolek, Wolfdieter Springer
Published 2017-04-01

Hexokinases link DJ-1 to the PINK1/parkin pathway

by David N. Hauser, Adamantios Mamais, Melissa M. Conti, Christopher T. Primiani, Ravindran Kumaran, Allissa A. Dillman, Rebekah G. Langston, Alexandra Beilina, Joseph H. Garcia, Alberto Diaz-Ruiz, Michel Bernier, Fabienne C. Fiesel, Xu Hou, Wolfdieter Springer, Yan Li, Rafael de Cabo, Mark R. Cookson
Published 2017-09-01

PINK1 Primes Parkin-Mediated Ubiquitination of PARIS in Dopaminergic Neuronal Survival

by Yunjong Lee, Daniel A. Stevens, Sung-Ung Kang, Haisong Jiang, Yun-Il Lee, Han Seok Ko, Leslie A. Scarffe, George E. Umanah, Hojin Kang, Sangwoo Ham, Tae-In Kam, Kathleen Allen, Saurav Brahmachari, Jungwoo Wren Kim, Stewart Neifert, Seung Pil Yun, Fabienne C. Fiesel, Wolfdieter Springer, Valina L. Dawson, Joo-Ho Shin, Ted M. Dawson
Published 2017-01-01