Alternative Pathways of Cancer Cell Death by Rottlerin: Apoptosis versus Autophagy

Since the ability of cancer cells to evade apoptosis often limits the efficacy of radiotherapy and chemotherapy, autophagy is emerging as an alternative target to promote cell death. Therefore, we wondered whether Rottlerin, a natural polyphenolic compound with antiproliferative effects in several c...

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Bibliographic Details
Main Authors: Claudia Torricelli, Sara Salvadori, Giuseppe Valacchi, Karel Souček, Eva Slabáková, Michela Muscettola, Nila Volpi, Emanuela Maioli
Format: Article
Language:English
Published: Hindawi Limited 2012-01-01
Series:Evidence-Based Complementary and Alternative Medicine
Online Access:http://dx.doi.org/10.1155/2012/980658