ZEB1: A Critical Regulator of Cell Plasticity, DNA Damage Response, and Therapy Resistance

by Stanislav Drápela, Stanislav Drápela, Stanislav Drápela, Jan Bouchal, Mohit Kumar Jolly, Zoran Culig, Zoran Culig, Karel Souček, Karel Souček, Karel Souček
Published 2020-03-01

3D Cell Culture Models Demonstrate a Role for FGF and WNT Signaling in Regulation of Lung Epithelial Cell Fate and Morphogenesis

by Anas Rabata, Radek Fedr, Radek Fedr, Karel Soucek, Karel Soucek, Ales Hampl, Ales Hampl, Zuzana Koledova
Published 2020-07-01

Toll-Like Receptor 3 in Solid Cancer and Therapy Resistance

by Ximena Maria Muresan, Jan Bouchal, Zoran Culig, Karel Souček
Published 2020-11-01

Phenotypic Heterogeneity of Triple-Negative Breast Cancer Mediated by Epithelial–Mesenchymal Plasticity

by Barbora Kvokačková, Ján Remšík, Mohit Kumar Jolly, Karel Souček
Published 2021-05-01

Rottlerin Inhibits ROS Formation and Prevents NFκB Activation in MCF-7 and HT-29 Cells

by Emanuela Maioli, Lucedio Greci, Karel Soucek, Martina Hyzdalova, Alessandra Pecorelli, Vittoria Fortino, Giuseppe Valacchi
Published 2009-01-01

Lung Neutrophilia in Myeloperoxidase Deficient Mice during the Course of Acute Pulmonary Inflammation

by Silvie Kremserova, Tomas Perecko, Karel Soucek, Anna Klinke, Stephan Baldus, Jason P. Eiserich, Lukas Kubala
Published 2016-01-01

Alternative Pathways of Cancer Cell Death by Rottlerin: Apoptosis versus Autophagy

by Claudia Torricelli, Sara Salvadori, Giuseppe Valacchi, Karel Souček, Eva Slabáková, Michela Muscettola, Nila Volpi, Emanuela Maioli
Published 2012-01-01

Slug-expressing mouse prostate epithelial cells have increased stem cell potential

by Zuzana Kahounová, Ján Remšík, Radek Fedr, Jan Bouchal, Alena Mičková, Eva Slabáková, Lucia Binó, Aleš Hampl, Karel Souček
Published 2020-07-01

Ring-Substituted 1-Hydroxynaphthalene-2-Carboxanilides Inhibit Proliferation and Trigger Mitochondria-Mediated Apoptosis

by Tereza Kauerová, Tomáš Goněc, Josef Jampílek, Susanne Hafner, Ann-Kathrin Gaiser, Tatiana Syrovets, Radek Fedr, Karel Souček, Peter Kollar
Published 2020-05-01

Skp2 and Slug Are Coexpressed in Aggressive Prostate Cancer and Inhibited by Neddylation Blockade

by Alena Mickova, Gvantsa Kharaishvili, Daniela Kurfurstova, Mariam Gachechiladze, Milan Kral, Ondrej Vacek, Barbora Pokryvkova, Martin Mistrik, Karel Soucek, Jan Bouchal
Published 2021-03-01

Chk1 Inhibitor SCH900776 Effectively Potentiates the Cytotoxic Effects of Platinum-Based Chemotherapeutic Drugs in Human Colon Cancer Cells

by Jarmila Herůdková, Kamil Paruch, Prashant Khirsariya, Karel Souček, Martin Krkoška, Olga Vondálová Blanářová, Petr Sova, Alois Kozubík, Alena Hyršlová Vaculová
Published 2017-10-01

BRCA1 or CDK12 loss sensitizes cells to CHK1 inhibitors

by Hana Paculová, Juraj Kramara, Šárka Šimečková, Radek Fedr, Karel Souček, Ondřej Hylse, Kamil Paruch, Marek Svoboda, Martin Mistrík, Jiří Kohoutek
Published 2017-10-01

Flavonoid 4′-O-Methylkuwanon E from Morus alba Induces the Differentiation of THP-1 Human Leukemia Cells

by Peter Kollar, Tomáš Bárta, Stanislava Keltošová, Pavlína Trnová, Veronika Müller Závalová, Karel Šmejkal, Jan Hošek, Radek Fedr, Karel Souček, Aleš Hampl
Published 2015-01-01

Prenylated Flavonoids from Morus alba L. Cause Inhibition of G1/S Transition in THP-1 Human Leukemia Cells and Prevent the Lipopolysaccharide-Induced Inflammatory Response

by Peter Kollar, Tomáš Bárta, Jan Hošek, Karel Souček, Veronika Müller Závalová, Shushan Artinian, Rabih Talhouk, Karel Šmejkal, Pavel Suchý, Aleš Hampl
Published 2013-01-01

Generation of human iPSCs from fetal prostate fibroblasts HPrF

by Zuzana Kahounová, Eva Slabáková, Lucia Binó, Ján Remšík, Radek Fedr, Jan Bouchal, Radek Vrtěl, Lucie Jurečková, Volodymyr Porokh, Darja Páralová, Aleš Hampl, Karel Souček
Published 2019-03-01

Generation of human iPSCs from human prostate cancer-associated fibroblasts IBPi002-A

by Zuzana Kahounová, Eva Slabáková, Lucia Binó, Ján Remšík, Radek Fedr, Jan Bouchal, Daniela Kurfűrstová, Radek Vrtěl, Vladimír Študent, Lucie Jurečková, Volodymyr Porokh, Aleš Hampl, Karel Souček
Published 2018-12-01

Comparative cell cycle transcriptomics reveals synchronization of developmental transcription factor networks in cancer cells.

by Johan Boström, Zuzana Sramkova, Alena Salašová, Helena Johard, Diana Mahdessian, Radek Fedr, Carolyn Marks, Jiřina Medalová, Karel Souček, Emma Lundberg, Sten Linnarsson, Vítězslav Bryja, Petra Sekyrova, Mikael Altun, Michael Andäng
Published 2017-01-01

The CHK1 inhibitor MU380 significantly increases the sensitivity of human docetaxel‐resistant prostate cancer cells to gemcitabine through the induction of mitotic catastrophe

by Stanislav Drápela, Prashant Khirsariya, Wytske M. vanWeerden, Radek Fedr, Tereza Suchánková, Diana Búzová, Jan Červený, Aleš Hampl, Martin Puhr, William R. Watson, Zoran Culig, Lumír Krejčí, Kamil Paruch, Karel Souček
Published 2020-10-01