The collagen chaperone HSP47 is a new interactor of APP that affects the levels of extracellular beta-amyloid peptides.

The collagen chaperone HSP47 is a new interactor of APP that affects the levels of extracellular beta-amyloid peptides.

Alzheimer disease (AD) is a neurodegenerative disorder characterized by progressive decline of cognitive function that represents one of the most dramatic medical challenges for the aging population. Aβ peptides, generated by processing of the Amyloid Precursor Protein (APP), are thought to play a c...

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Bibliographic Details
Main Authors: Federico T Bianchi, Paola Camera, Ugo Ala, Daniele Imperiale, Antonio Migheli, Enrica Boda, Filippo Tempia, Gaia Berto, Ylenia Bosio, Salvatore Oddo, Frank M LaFerla, Stefano Taraglio, Carlos G Dotti, Ferdinando Di Cunto
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3145648?pdf=render

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http://europepmc.org/articles/PMC3145648?pdf=render

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