Leptin Activates RhoA/ROCK Pathway to Induce Cytoskeleton Remodeling in Nucleus Pulposus Cells

Leptin Activates RhoA/ROCK Pathway to Induce Cytoskeleton Remodeling in Nucleus Pulposus Cells

Hyperleptinemia is implicated in obesity-associated lumbar disc degeneration. Nevertheless, the effect of leptin on the intracellular signaling of nucleus pulposus cells is not clear. The current study sought to delineate the possible involvement of the RhoA/ROCK pathway in leptin-mediated cytoskel...

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Bibliographic Details
Main Authors: Zheng Li, Jinqian Liang, William Ka Kei Wu, Xin Yu, Jun Yu, Xisheng Weng, Jianxiong Shen
Format: Article
Language:English
Published: MDPI AG 2014-01-01
Series:International Journal of Molecular Sciences
Subjects:
disc degeneration
fluorescent resonance energy transfer (FRET)
cytoskeleton
leptin
F-actin
Online Access:http://www.mdpi.com/1422-0067/15/1/1176

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http://www.mdpi.com/1422-0067/15/1/1176

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