Nanobody-Enhanced Targeting of AAV Gene Therapy Vectors

Nanobody-Enhanced Targeting of AAV Gene Therapy Vectors

A limiting factor for the use of adeno-associated viruses (AAVs) as vectors in gene therapy is the broad tropism of AAV serotypes, i.e., the parallel infection of several cell types. Nanobodies are single immunoglobulin variable domains from heavy chain antibodies that naturally occur in camelids. T...

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Bibliographic Details
Main Authors: Anna Marei Eichhoff, Kathleen Börner, Birte Albrecht, Waldemar Schäfer, Natalie Baum, Friedrich Haag, Jakob Körbelin, Martin Trepel, Ingke Braren, Dirk Grimm, Sahil Adriouch, Friedrich Koch-Nolte
Format: Article
Language:English
Published: Elsevier 2019-12-01
Series:Molecular Therapy: Methods & Clinical Development
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050119301019

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http://www.sciencedirect.com/science/article/pii/S2329050119301019

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