Overexpression of the transcription factor Yap1 modifies intracellular redox conditions and enhances recombinant protein secretion

Overexpression of the transcription factor Yap1 modifies intracellular redox conditions and enhances recombinant protein secretion

Oxidative folding of secretory proteins in the endoplasmic reticulum (ER) is a redox active process, which also impacts the redox conditions in the cytosol. As the transcription factor Yap1 is involved in the transcriptional response to oxidative stress, we investigate its role upon the production o...

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Bibliographic Details
Main Authors: Marizela Delic, Alexandra B. Graf, Gunda Koellensperger, Christina Haberhauer-Troyer, Stephan Hann, Diethard Mattanovich, Brigitte Gasser
Format: Article
Language:English
Published: Shared Science Publishers OG 2014-10-01
Series:Microbial Cell
Subjects:
ER
cytosol
cellular redox regulation
oxidative protein folding
glutathione
redox sensitive roGFP
Pichia pastoris
Online Access:http://microbialcell.com/researcharticles/overexpression-of-the-transcription-factor-yap1-modifies-intracellular-redox-conditions-and-enhances-recombinant-protein-secretion/

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http://microbialcell.com/researcharticles/overexpression-of-the-transcription-factor-yap1-modifies-intracellular-redox-conditions-and-enhances-recombinant-protein-secretion/

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