Recombinant Adeno-Associated Virus Serotype 6 (rAAV6) Potently and Preferentially Transduces Rat Astrocytes in vitro and in vivo

Recombinant AAV vectors are an increasingly popular tool for gene delivery to the CNS because of their non-pathological nature, low immunogenicity, and ability to stably transduce dividing and non-dividing cells. One of the limitations of rAAVs is their preferential tropism for neuronal cells. Gli...

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Bibliographic Details
Main Authors: Alexandra L. Schober, Dmitriy A. Gagarkin, Ying Chen, Guangping Gao, Lauren Jacobson, Alexander A. Mongin
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-11-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2016.00262/full