Canavan Disease as a Model for Gene Therapy-Mediated Myelin Repair

by Anoushka Lotun, Anoushka Lotun, Dominic J. Gessler, Dominic J. Gessler, Dominic J. Gessler, Guangping Gao, Guangping Gao, Guangping Gao
Published 2021-04-01

Vectored Immunotherapeutics for Infectious Diseases: Can rAAVs Be The Game Changers for Fighting Transmissible Pathogens?

by Wei Zhan, Wei Zhan, Manish Muhuri, Manish Muhuri, Manish Muhuri, Phillip W. L. Tai, Phillip W. L. Tai, Phillip W. L. Tai, Guangping Gao, Guangping Gao, Guangping Gao, Guangping Gao
Published 2021-05-01

Rational design of aptazyme riboswitches for efficient control of gene expression in mammalian cells

by Guocai Zhong, Haimin Wang, Charles C Bailey, Guangping Gao, Michael Farzan
Published 2016-11-01

Viral vector platforms within the gene therapy landscape

by Jote T. Bulcha, Yi Wang, Hong Ma, Phillip W. L. Tai, Guangping Gao
Published 2021-02-01

Recombinant AAV Vectors for Enhanced Expression of Authentic IgG.

by Sebastian P Fuchs, José M Martinez-Navio, Guangping Gao, Ronald C Desrosiers
Published 2016-01-01

Liver-Directed but Not Muscle-Directed AAV-Antibody Gene Transfer Limits Humoral Immune Responses in Rhesus Monkeys

by Sebastian P. Fuchs, José M. Martinez-Navio, Eva G. Rakasz, Guangping Gao, Ronald C. Desrosiers
Published 2020-03-01

Recombinant Adeno-Associated Virus Serotype 6 (rAAV6) Potently and Preferentially Transduces Rat Astrocytes in vitro and in vivo

by Alexandra L. Schober, Dmitriy A. Gagarkin, Ying Chen, Guangping Gao, Lauren Jacobson, Alexander A. Mongin
Published 2016-11-01

Glycoengineering of AAV-delivered monoclonal antibodies yields increased ADCC activity

by James M. Termini, José M. Martinez-Navio, Guangping Gao, Sebastian P. Fuchs, Ronald C. Desrosiers
Published 2021-03-01

Streamlined ex vivo and in vivo genome editing in mouse embryos using recombinant adeno-associated viruses

by Yeonsoo Yoon, Dan Wang, Phillip W. L. Tai, Joy Riley, Guangping Gao, Jaime A. Rivera-Pérez
Published 2018-01-01

CNS-restricted Transduction and CRISPR/Cas9-mediated Gene Deletion with an Engineered AAV Vector

by Giridhar Murlidharan, Kensuke Sakamoto, Lavanya Rao, Travis Corriher, Dan Wang, Guangping Gao, Patrick Sullivan, Aravind Asokan
Published 2016-01-01

MicroRNA-96 Promotes Schistosomiasis Hepatic Fibrosis in Mice by Suppressing Smad7

by Xufeng Luo, Dongmei Zhang, Jun Xie, Qin Su, Xing He, Ruipu Bai, Guangping Gao, Weiqing Pan
Published 2018-12-01

AAV-Delivered Antibody Mediates Significant Protective Effects against SIVmac239 Challenge in the Absence of Neutralizing Activity.

by Sebastian P Fuchs, José M Martinez-Navio, Michael Piatak, Jeffrey D Lifson, Guangping Gao, Ronald C Desrosiers
Published 2015-08-01

Inhibition or Stimulation of Autophagy Affects Early Formation of Lipofuscin-Like Autofluorescence in the Retinal Pigment Epithelium Cell

by Lei Lei, Radouil Tzekov, Huapeng Li, J. Hugh McDowell, Guangping Gao, W. Clay Smith, Shibo Tang, Shalesh Kaushal
Published 2017-03-01

Down-regulation of microRNA-203-3p initiates type 2 pathology during schistosome infection via elevation of interleukin-33.

by Xing He, Jun Xie, Yange Wang, Xiaobin Fan, Qin Su, Yue Sun, Nanhang Lei, Dongmei Zhang, Guangping Gao, Weiqing Pan
Published 2018-03-01

Bone-targeting AAV-mediated silencing of Schnurri-3 prevents bone loss in osteoporosis

by Yeon-Suk Yang, Jun Xie, Dan Wang, Jung-Min Kim, Phillip W. L. Tai, Ellen Gravallese, Guangping Gao, Jae-Hyuck Shim
Published 2019-07-01

Long-Term Delivery of an Anti-SIV Monoclonal Antibody With AAV

by José M. Martinez-Navio, Sebastian P. Fuchs, Desiree E. Mendes, Eva G. Rakasz, Guangping Gao, Jeffrey D. Lifson, Ronald C. Desrosiers
Published 2020-03-01

Empty virions in AAV8 vector preparations reduce transduction efficiency and may cause total viral particle dose-limiting side effects

by Kai Gao, Mengxin Li, Li Zhong, Qin Su, Jia Li, Shaoyong Li, Ran He, Yu Zhang, Gregory Hendricks, Junzhi Wang, Guangping Gao
Published 2014-01-01

Novel Combinatorial MicroRNA-Binding Sites in AAV Vectors Synergistically Diminish Antigen Presentation and Transgene Immunity for Efficient and Stable Transduction

by Manish Muhuri, Manish Muhuri, Manish Muhuri, Wei Zhan, Wei Zhan, Wei Zhan, Yukiko Maeda, Yukiko Maeda, Yukiko Maeda, Jia Li, Jia Li, Anoushka Lotun, Jennifer Chen, Katelyn Sylvia, Katelyn Sylvia, Ishani Dasgupta, Ishani Dasgupta, Motahareh Arjomandnejad, Motahareh Arjomandnejad, Thomas Nixon, Thomas Nixon, Allison M. Keeler, Allison M. Keeler, Sangeetha Manokaran, Ran He, Qin Su, Phillip W. L. Tai, Phillip W. L. Tai, Phillip W. L. Tai, Guangping Gao, Guangping Gao, Guangping Gao
Published 2021-04-01

Gene Delivery to Nonhuman Primate Preimplantation Embryos Using Recombinant Adeno‐Associated Virus

by Dan Wang, Yuyu Niu, Lingzhi Ren, Yu Kang, Phillip W. L. Tai, Chenyang Si, Craig A. Mendonca, Hong Ma, Guangping Gao, Weizhi Ji
Published 2019-11-01

Adeno-associated Virus Genome Population Sequencing Achieves Full Vector Genome Resolution and Reveals Human-Vector Chimeras

by Phillip W.L. Tai, Jun Xie, Kaiyuen Fong, Matthew Seetin, Cheryl Heiner, Qin Su, Michael Weiand, Daniella Wilmot, Maria L. Zapp, Guangping Gao
Published 2018-06-01