Genetic modifiers ameliorate endocytic and neuromuscular defects in a model of spinal muscular atrophy

Genetic modifiers ameliorate endocytic and neuromuscular defects in a model of spinal muscular atrophy

Abstract Background Understanding the genetic modifiers of neurodegenerative diseases can provide insight into the mechanisms underlying these disorders. Here, we examine the relationship between the motor neuron disease spinal muscular atrophy (SMA), which is caused by reduced levels of the surviva...

Full description

Bibliographic Details
Main Authors: Melissa B. Walsh, Eva Janzen, Emily Wingrove, Seyyedmohsen Hosseinibarkooie, Natalia Rodriguez Muela, Lance Davidow, Maria Dimitriadi, Erika M. Norabuena, Lee L. Rubin, Brunhilde Wirth, Anne C. Hart
Format: Article
Language:English
Published: BMC 2020-09-01
Series:BMC Biology
Subjects:
PLS3
hnRNP
Neurodegenerative disease
SMN
SMA
Endocytosis
Online Access:http://link.springer.com/article/10.1186/s12915-020-00845-w

Internet

http://link.springer.com/article/10.1186/s12915-020-00845-w

Similar Items