Neurodegenerative disorders: Insights from the nematode Caenorhabditis elegans

by Maria Dimitriadi, Anne C. Hart
Published 2010-10-01

In Vivo Modelling of ATP1A3 G316S-Induced Ataxia in C. elegans Using CRISPR/Cas9-Mediated Homologous Recombination Reveals Dominant Loss of Function Defects.

by Altar Sorkaç, Ivan C Alcantara, Anne C Hart
Published 2016-01-01

Genome-Wide Screen for Genes Involved in Caenorhabditis elegans Developmentally Timed Sleep

by Huiyan Huang, Chen-Tseh Zhu, Lukas L. Skuja, Dustin J. Hayden, Anne C. Hart
Published 2017-09-01

Identification of potential therapeutic drugs for huntington's disease using Caenorhabditis elegans.

by Cindy Voisine, Hemant Varma, Nicola Walker, Emily A Bates, Brent R Stockwell, Anne C Hart
Published 2007-06-01

A V-to-F substitution in SK2 channels causes Ca2+ hypersensitivity and improves locomotion in a C. elegans ALS model

by Young-Woo Nam, Saba N. Baskoylu, Dimitris Gazgalis, Razan Orfali, Meng Cui, Anne C. Hart, Miao Zhang
Published 2018-07-01

Normal sleep bouts are not essential for C. elegans survival and FoxO is important for compensatory changes in sleep

by Heather L. Bennett, Yulia Khoruzhik, Dustin Hayden, Huiyan Huang, Jarred Sanders, Melissa B. Walsh, David Biron, Anne C. Hart
Published 2018-03-01

A pilot prospective study of sleep patterns and DNA methylation-characterized epigenetic aging in young adults

by Mary A. Carskadon, Kenneth R. Chappell, David H. Barker, Anne C. Hart, Kayla Dwyer, Caroline Gredvig-Ardito, Caitlyn Starr, John E. McGeary
Published 2019-09-01

Single copy/knock-in models of ALS SOD1 in C. elegans suggest loss and gain of function have different contributions to cholinergic and glutamatergic neurodegeneration.

by Saba N Baskoylu, Jill Yersak, Patrick O'Hern, Sarah Grosser, Jonah Simon, Sarah Kim, Kelsey Schuch, Maria Dimitriadi, Katherine S Yanagi, Jeremy Lins, Anne C Hart
Published 2018-10-01

Decreased microRNA levels lead to deleterious increases in neuronal M2 muscarinic receptors in Spinal Muscular Atrophy models

by Patrick J O'Hern, Inês do Carmo G. Gonçalves, Johanna Brecht, Eduardo Javier López Soto, Jonah Simon, Natalie Chapkis, Diane Lipscombe, Min Jeong Kye, Anne C Hart
Published 2017-05-01

Genetic modifiers ameliorate endocytic and neuromuscular defects in a model of spinal muscular atrophy

by Melissa B. Walsh, Eva Janzen, Emily Wingrove, Seyyedmohsen Hosseinibarkooie, Natalia Rodriguez Muela, Lance Davidow, Maria Dimitriadi, Erika M. Norabuena, Lee L. Rubin, Brunhilde Wirth, Anne C. Hart
Published 2020-09-01

OSM-11 facilitates LIN-12 Notch signaling during Caenorhabditis elegans vulval development.

by Hidetoshi Komatsu, Michael Y Chao, Jonah Larkins-Ford, Mark E Corkins, Gerard A Somers, Tim Tucey, Heather M Dionne, Jamie Q White, Khursheed Wani, Mike Boxem, Anne C Hart
Published 2008-08-01

Modeling spinal muscular atrophy in Drosophila.

by Howard Chia-Hao Chang, Douglas N Dimlich, Takakazu Yokokura, Ashim Mukherjee, Mark W Kankel, Anindya Sen, Vasanthi Sridhar, Tudor A Fulga, Anne C Hart, David Van Vactor, Spyros Artavanis-Tsakonas
Published 2008-09-01

Conserved genes act as modifiers of invertebrate SMN loss of function defects.

by Maria Dimitriadi, James N Sleigh, Amy Walker, Howard C Chang, Anindya Sen, Geetika Kalloo, Jevede Harris, Tom Barsby, Melissa B Walsh, John S Satterlee, Chris Li, David Van Vactor, Spyros Artavanis-Tsakonas, Anne C Hart
Published 2010-10-01