A chemical proteomic atlas of brain serine hydrolases identifies cell type-specific pathways regulating neuroinflammation

Metabolic specialization among major brain cell types is central to nervous system function and determined in large part by the cellular distribution of enzymes. Serine hydrolases are a diverse enzyme class that plays fundamental roles in CNS metabolism and signaling. Here, we perform an activity-ba...

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Bibliographic Details
Main Authors: Andreu Viader, Daisuke Ogasawara, Christopher M Joslyn, Manuel Sanchez-Alavez, Simone Mori, William Nguyen, Bruno Conti, Benjamin F Cravatt
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-01-01
Series:eLife
Subjects:
Online Access:https://elifesciences.org/articles/12345