Lysosome-Dependent LXR and PPARδ Activation Upon Efferocytosis in Human Macrophages

Lysosome-Dependent LXR and PPARδ Activation Upon Efferocytosis in Human Macrophages

Efferocytosis is critical for tissue homeostasis, as its deregulation is associated with several autoimmune pathologies. While engulfing apoptotic cells, phagocytes activate transcription factors, such as peroxisome proliferator-activated receptors (PPAR) or liver X receptors (LXR) that orchestrate...

Full description

Bibliographic Details
Main Authors: Ana Carolina Mota, Monica Dominguez, Andreas Weigert, Ryan G. Snodgrass, Dmitry Namgaladze, Bernhard Brüne
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Immunology
Subjects:
macrophages
efferocytosis
apoptosis
peroxisome proliferator-activated receptor
liver X receptor
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.637778/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.637778/full

Similar Items