AcrIF9 tethers non-sequence specific dsDNA to the CRISPR RNA-guided surveillance complex

AcrIF9 tethers non-sequence specific dsDNA to the CRISPR RNA-guided surveillance complex

The anti-CRISPR protein IF9 (AcrIF9) specifically inhibits the type I-F CRISPR adaptive immune system. Here, the authors present the cryo-EM structure of AcrIF9 in complex with the type I-F CRISPR RNA-guided surveillance complex (Csy) and a dsDNA bound Csy-AcrIF9 structure, and find that AcrIF9 bind...

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Bibliographic Details
Main Authors: Marscha Hirschi, Wang-Ting Lu, Andrew Santiago-Frangos, Royce Wilkinson, Sarah M. Golden, Alan R. Davidson, Gabriel C. Lander, Blake Wiedenheft
Format: Article
Language:English
Published: Nature Publishing Group 2020-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-16512-1

Internet

https://doi.org/10.1038/s41467-020-16512-1

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