The Effects of Endogenous Non-Peptide Molecule Isatin and Hydrogen Peroxide on Proteomic Profiling of Rat Brain Amyloid-β Binding Proteins: Relevance to Alzheimer’s Disease?

The Effects of Endogenous Non-Peptide Molecule Isatin and Hydrogen Peroxide on Proteomic Profiling of Rat Brain Amyloid-β Binding Proteins: Relevance to Alzheimer’s Disease?

The amyloid-β peptide is considered as a key player in the development and progression of Alzheimer’s disease (AD). Although good evidence exists that amyloid-β accumulates inside cells, intracellular brain amyloid-binding proteins remain poorly characterized. Proteomic profiling of rat brain homoge...

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Bibliographic Details
Main Authors: Alexei E. Medvedev, Olga A. Buneeva, Arthur T. Kopylov, Oksana V. Gnedenko, Marina V. Medvedeva, Sergey A. Kozin, Alexis S. Ivanov, Victor G. Zgoda, Alexander A. Makarov
Format: Article
Language:English
Published: MDPI AG 2014-12-01
Series:International Journal of Molecular Sciences
Subjects:
amyloid-β
amyloid-β binding proteins
proteomic profiling
rat brain
isatin
oxidative stress
Online Access:http://www.mdpi.com/1422-0067/16/1/476

Internet

http://www.mdpi.com/1422-0067/16/1/476

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