RNF4-Dependent Oncogene Activation by Protein Stabilization

RNF4-Dependent Oncogene Activation by Protein Stabilization

Ubiquitylation regulates signaling pathways critical for cancer development and, in many cases, targets proteins for degradation. Here, we report that ubiquitylation by RNF4 stabilizes otherwise short-lived oncogenic transcription factors, including β-catenin, Myc, c-Jun, and the Notch intracellular...

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Bibliographic Details
Main Authors: Jane J. Thomas, Mona Abed, Julian Heuberger, Rostislav Novak, Yaniv Zohar, Angela P. Beltran Lopez, Julie S. Trausch-Azar, Ma. Xenia G. Ilagan, David Benhamou, Gunnar Dittmar, Raphael Kopan, Walter Birchmeier, Alan L. Schwartz, Amir Orian
Format: Article
Language:English
Published: Elsevier 2016-09-01
Series:Cell Reports
Subjects:
STUbL
ubiquitin
SUMO
gene regulation
oncogenes
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716310713

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http://www.sciencedirect.com/science/article/pii/S2211124716310713

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