Pre- and peri-implantation Zika virus infection impairs fetal development by targeting trophectoderm cells

Pre- and peri-implantation Zika virus infection impairs fetal development by targeting trophectoderm cells

Here, using human cells and mouse models, the authors show that Zika virus can infect preimplantation trophectoderm. Pre-implantation infection can affect nervous system development and survival of neural progenitors, and can result in miscarriage or spontaneous abortion.

Bibliographic Details
Main Authors: Lei Tan, Lauretta A. Lacko, Ting Zhou, Delia Tomoiaga, Romulo Hurtado, Tuo Zhang, Ana Sevilla, Aaron Zhong, Christopher E Mason, Scott Noggle, Todd Evans, Heidi Stuhlmann, Robert E. Schwartz, Shuibing Chen
Format: Article
Language:English
Published: Nature Publishing Group 2019-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-12063-2

Internet

https://doi.org/10.1038/s41467-019-12063-2

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