Brain Histamine Modulates the Antidepressant-Like Effect of the 3-Iodothyroacetic Acid (TA1)

Brain Histamine Modulates the Antidepressant-Like Effect of the 3-Iodothyroacetic Acid (TA1)

3-iodothyroacetic acid (TA1), an end metabolite of thyroid hormone, has been shown to produce behavioral effects in mice that are dependent on brain histamine. We now aim to verify whether pharmacologically administered TA1 has brain bioavailability and is able to induce histamine-dependent antidepr...

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Bibliographic Details
Main Authors: Annunziatina Laurino, Elisa Landucci, Lorenzo Cinci, Manuela Gencarelli, Gaetano De Siena, Lorenza Bellusci, Grazia Chiellini, Laura Raimondi
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Cellular Neuroscience
Subjects:
3-iodothyroacetic acid
thyroid hormone
histamine
mast cells
antidepressant effect
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2019.00176/full

Internet

https://www.frontiersin.org/article/10.3389/fncel.2019.00176/full

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