NADPH oxidase limits innate immune responses in the lungs in mice.

NADPH oxidase limits innate immune responses in the lungs in mice.

Chronic granulomatous disease (CGD), an inherited disorder of the NADPH oxidase in which phagocytes are defective in generating superoxide anion and downstream reactive oxidant intermediates (ROIs), is characterized by recurrent bacterial and fungal infections and by excessive inflammation (e.g., in...

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Bibliographic Details
Main Authors: Brahm H Segal, Wei Han, Jennifer J Bushey, Myungsoo Joo, Zahida Bhatti, Joy Feminella, Carly G Dennis, R Robert Vethanayagam, Fiona E Yull, Maegan Capitano, Paul K Wallace, Hans Minderman, John W Christman, Michael B Sporn, Jefferson Chan, Donald C Vinh, Steven M Holland, Luigina R Romani, Sarah L Gaffen, Michael L Freeman, Timothy S Blackwell
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-03-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2838778?pdf=render

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http://europepmc.org/articles/PMC2838778?pdf=render

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