Human plasminogen-derived N-acetyl-Arg-Leu-Tyr-Glu antagonizes VEGFR-2 to prevent blood-retinal barrier breakdown in diabetic mice

Human plasminogen-derived N-acetyl-Arg-Leu-Tyr-Glu antagonizes VEGFR-2 to prevent blood-retinal barrier breakdown in diabetic mice

Targeting the vascular endothelial growth factor (VEGF)/its receptor-2 (VEGFR-2) system has become a mainstay of treatment for many human diseases, including retinal diseases. We examined the therapeutic effect of recently developed N-acetylated Arg-Leu-Tyr-Glu (Ac-RLYE), a human plasminogen kringle...

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Bibliographic Details
Main Authors: Wonjin Park, Joohwan Kim, Seunghwan Choi, Taesam Kim, Minsik Park, Suji Kim, Ji-Chang You, Jeong Hun Kim, Kwon-Soo Ha, Jeong-Hyung Lee, Young-Guen Kwon, Young-Myeong Kim
Format: Article
Language:English
Published: Elsevier 2021-02-01
Series:Biomedicine & Pharmacotherapy
Subjects:
VEGFR-2 antagonist
Vascular leakage
Blood-retinal barrier
Diabetic retinopathy
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332220313032

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http://www.sciencedirect.com/science/article/pii/S0753332220313032

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